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Considering elevated levels of senescent pulmonary cells in smokers with COPD 9,10,11,28 , our current findings that acute CSE exposure induces CCR6 + Th17 cells premature senescence can at least partially also explain the resultant systemic accumulation of CCR6 + Th17 cells 4,5,6,7 , and contribute to higher CCR6 + /CCR6 T cells ratio in healthy smokers